Hydroquinone is one of the most effective topical treatments for Melasma, as it works by reducing melanin production to gradually lighten dark patches over several weeks to months. Commonly, concentrations of 2% (over-the-counter) to 4% (prescription strength) are used, with treatment typically recommended for up to 3–6 months under medical supervision to avoid complications. While many people see improvement, possible side effects include skin irritation, redness, dryness, and, with long-term or improper use, a rare condition called ochronosis (bluish-dark skin discoloration). It’s important to use sunscreen daily and consult a dermatologist before long-term use, especially if you have sensitive skin or if the pigmentation does not improve, as combination treatments may sometimes work better.