Yes, some toothpaste ingredients can trigger or worsen perioral dermatitis, especially fluoride, sodium lauryl sulfate (SLS), and strong flavoring agents like mint or cinnamon, because they can irritate sensitive facial skin or disrupt the skin barrier around the mouth. Perioral dermatitis often appears around the mouth, nose, and sometimes eyes because these areas have thin, sensitive skin that is easily affected by topical products, cosmetics, and repeated irritation (like licking lips, toothpaste residue, or steroid creams), which can trigger inflammation and a rash-like flare. To help reduce flare-ups, doctors often recommend switching to a gentle, SLS-free and sometimes fluoride-free toothpaste (if advised), avoiding heavy creams or steroid creams on the face, using mild fragrance-free skincare, and simplifying routines to a gentle cleanser and light moisturizer only. Avoiding overuse of cosmetics and harsh exfoliants also helps the skin barrier recover and reduces recurrence.